Observational analysis reveals IADL disability mediates the link between circadian syndrome and new-onset CMM in adults, suggesting pathways for prevention.
Our study highlighted that CirS and increasing number of components associated with CMM. The combination of CirS and IADL disability was significantly associated with new-onset CMM. In addition, IADL disability mediated the effect of CirS on the progression to CMM, accounting for 8.37% of the total effect. Our findings provided new insights into prevention of CMM.
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Fang et al. (2025) studied this question.
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