Synthesis, antibacterial activity, and mechanistic characterization of novel 9-substituted berberine derivatives

Jianbo Tong; Kejie Chen; H.‐J. HAN

doi:10.1039/d5md00825e

December 2, 2025RSC Medicinal Chemistry

Synthesis, antibacterial activity, and mechanistic characterization of novel 9-substituted berberine derivatives

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Key Points

Antibacterial agents displayed significant growth inhibition against various bacterial strains.
Approximately 35 novel berberine derivatives were synthesized and screened for activity.
Assessment involved mechanistic characterization of the antibacterial effects of the derivatives.
Natural products provide a valuable foundation for discovering new antibacterial agents.

Implication

Synthesis of berberine derivatives showed effective growth inhibition in bacterial strains, suggesting potential as antibacterial agents.

Abstract

Natural products serve as valuable sources for developing antibacterial agents. In this study, 35 berberine derivatives were synthesized, and preliminary screening revealed that most compounds effectively inhibited the growth of...

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Cite This Study

Tong et al. (2025) studied this question.

synapsesocial.com/papers/69337cceb3f947a0a1259d50 https://doi.org/10.1039/d5md00825e

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Synthesis, antibacterial activity, and mechanistic characterization of novel 9-substituted berberine derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis, antibacterial activity, and mechanistic characterization of novel 9-substituted berberine derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

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