Analysis reveals neuroprotective triiodothyronine mechanisms that mitigate brain damage in neonatal hypoxic-ischemic encephalopathy, indicating new therapeutic avenues.
We defined a previously unrecognized neuroprotective astrocyte subpopulation and revealed temporal heterogeneity in astrocytic inflammatory responses in HIE. We also identified a T3-mediated astrocyte-neuron crosstalk mechanism that mitigated HIBD, highlighting a tractable therapeutic avenue.
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Yang et al. (2025) studied this question.
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