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December 6, 2025Frontiers in PsychiatryOpen Access

Exploring the molecular mechanisms of phthalates in the comorbidity of preeclampsia and depression by integrating multiple datasets

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Authors

XGXia GuYZYaqiong ZhangYMYantuanjin Ma

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Overview

Differential expression analysis identifies shared mechanisms in preeclampsia and depression, suggesting molecular targets for diagnosis.

Key Points

  • Preeclampsia and depression showed mutual influences through molecular mechanisms, highlighting shared pathways.
  • Four hundred thirty-four genes associated with preeclampsia and over a thousand linked to depression were analyzed.
  • Machine learning algorithms identified diagnostic genes in placental and blood transcriptomes across multiple datasets.
  • The study suggests environmental compounds may play a role in the comorbidity of preeclampsia and depression.

Cite This Study

Gu et al. (2025) studied this question.

synapsesocial.com/papers/69337cdbb3f947a0a1259f0dhttps://doi.org/10.3389/fpsyt.2025.1596995
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