Metabolomic analysis identifies dysregulated pathways in osteoporosis, suggesting targets for therapeutic intervention and validation.
This study provides the first comprehensive metabolomic profile of human osteoporotic cancellous bone, highlighting a network of metabolic disturbances that underlie dysregulated bone remodeling. These findings identify amino acid, purine, and phospholipid pathways as potential mechanistic drivers and therapeutic targets in osteoporosis. Metabolites with strong statistical significance warrant further validation and translational investigation.
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Long et al. (2025) studied this question.
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