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Study shows enhanced accuracy in sentinel lymph node assessment with neoadjuvant chemotherapy in HER2-positive and hormone receptor-positive breast cancer patients, suggesting tailored management.
Collectively, our study demonstrates that ITPC exhibits a robust accuracy for detecting SLN metastases in cN + breast cancer patients treated with NAC. The findings support the implementation of molecular subtype-specific SLN management: ITPC alone may be adequate for HER2-positive and TNBC tumors; for hormone receptor-positive (Luminal) subtypes, ITPC may need to be combined with molecular/immunohistochemical analysis.
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Chen et al. (2025) studied this question.
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