Case report reveals that rituximab therapy improves symptoms in a man with suspected Crohn disease, indicating the need for precise diagnosis and management.
We present the case of a 36-year-old man initially diagnosed with Crohn disease who was nonresponsive to numerous advanced therapies. Further evaluation revealed diffuse lymphadenopathy, severe enterocolitis, and significantly elevated immunoglobulin G4 levels. Staining of colonic biopsies confirmed IgG4-related enterocolitis. Treatment with rituximab therapy and dose adjustment guided by clinical symptoms, stool calprotectin, and intestinal ultrasound resulted in symptomatic, endoscopic, histologic, and transmural healing.
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Duty et al. (2025) studied this question.
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