Three New Phenolic Compounds From the Twigs and Leaves of Casearia glomerata

Phytochemical studies of the twigs and leaves of Casearia glomerata yielded three previously undescribed phenolic compounds, including two phenylpropanoid derivatives, Casearata A ( 1 ) and Casearata B ( 2 ), one butyrolactone, Casearata C ( 3 ), as well as eleven known compounds 4 – 14 . Their structures were elucidated by nuclear magnetic resonance, infrared, mass spectrometry, and ultraviolet spectroscopy. The absolute configurations of the new compounds were determined by a combination of linear correlation coefficients ( R 2 ), DP4+ probability analysis, and electronic circular dichroism calculations. The cytotoxic activity of compounds 1 – 4 and 6 – 14 was evaluated. Among these, compound 7 exhibited weak inhibitory effects against MDA‐MB‐231, HCT‐116, HepG2, and A549 tumor cell lines, with IC 50 values of 21.70–39.08 µM.