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December 8, 2025Dalton Transactions2 citations

Comprehensive Design, Synthesis of Methyl Substituted Benzimidazole-based Mononuclear Copper(II) Complexes and Evaluation of DNA Cleavage and ROS-induced Apoptosis

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MKManoj Kumar KumawatSMShobhit MathurSRSharan Shanmuga Vuppaladadium Rathnam

Key Points

  • Copper(II) complex shows DNA cleavage activity, with implications for anticancer mechanisms.
  • The copper(II) complex involving 2,2'-bipyridine produced significant results in biological assays.
  • The study involved synthesizing and assessing novel copper(II) complexes with benzimidazole derivatives.
  • Further exploration could provide insights into new cancer treatment strategies involving copper complexes.

Abstract

Four novel mononuclear Cu(II) mixed ligand complexes Cu(L)(NN/)(ClO4)2 1−4, where L is Bis-((1-methyl-1H-benzodimidazol-2-yl)methyl)amine and NN/ is 2,2/-bipyridine (bpy) (1), 1,10-phenanthroline (phen) (2), 2,9-dimethyl-1,10-phenanthroline (2,9-dmp) (3), or dipyrido3,2-d:2/,3/-f- quinoxaline (dpq) (4),...

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Cite This Study

Kumawat et al. (2025) studied this question.

synapsesocial.com/papers/693624984fa91c937236c0e3https://doi.org/10.1039/d5dt02281a
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