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December 8, 2025Green Chemistry2 citations

Electrochemically driven azide–alkyne cycloaddition (E-CuAAC) via anodic oxidation using dual copper electrodes

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DVDisha P. ValaMPMehul P. ParmarHPHitendra M Patel

Key Points

  • Increased efficiency of electrochemical azide-alkyne cycloaddition in a simplified format using dual copper electrodes.
  • Anodic oxidation facilitated this process at a constant voltage of +0.6 V in an undivided cell setup.
  • This method enhances the direct application of electrochemical synthesis while reducing complexity in reaction procedures.
  • Potential implications of this method may lead to easier synthesis of compounds in various chemical applications.

Abstract

A mechanistically accurate and electrochemically driven CuAAC in an undivided cell using dual copper electrodes held at a constant cell voltage of +0.6 V. This setup enables anodic oxidation to promote CuAAC, showing the simplicity of E-CuAAC. The image has been modified with AI (Microsoft Copilot).

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Cite This Study

Vala et al. (2025) studied this question.

synapsesocial.com/papers/693624ad4fa91c937236c659https://doi.org/10.1039/d5gc04792g
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