Genetic Spectrum of Negative Electroretinograms in a Predominantly Pediatric Cohort of 177 Patients

Kirill Zaslavsky; Anupreet Tumber; Eoghan Millar; Elise Héon; Ajoy Vincent

doi:10.1167/iovs.66.15.19

December 4, 2025Investigative Ophthalmology & Visual ScienceOpen Access

Genetic Spectrum of Negative Electroretinograms in a Predominantly Pediatric Cohort of 177 Patients

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Key Points

Myopia was associated with genetic factors in pediatric patients with negative electroretinograms.
Novel gene associations were identified, underscoring the need for genetic insight in myopia cases.
Observational analysis across a cohort of 177 patients revealed links between genetic variability and nERGs.
Findings highlight the role of the ON-bipolar pathway in myopia, warranting further genetic exploration.

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Abstract

This study expands the genetic spectrum underlying nERGs, confirming prior associations and identifying five novel genes associations. We provide evidence for the role of ON-bipolar pathway in myopia development. In photoreceptor dystrophies, nERGs rarely occur and likely represent a transient epiphenomenon independent of the underlying gene or mechanism.

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Zaslavsky et al. (2025) studied this question.

synapsesocial.com/papers/693624ba4fa91c937236ca87 https://doi.org/10.1167/iovs.66.15.19

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Genetic Spectrum of Negative Electroretinograms in a Predominantly Pediatric Cohort of 177 Patients

Key Points

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Genetic Spectrum of Negative Electroretinograms in a Predominantly Pediatric Cohort of 177 Patients

Key Points

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Abstract

Discussion

Cite This Study

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