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December 8, 2025NutrientsOpen Access

A Low-Cost, High-Fat Diet Effectively Induces Obesity and Metabolic Alterations and Diet Normalization Modulates Microbiota in C57BL/6 Mice

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Authors

MPMaria do Carmo Gouveia Pelúzio

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Overview

Observational analysis revealed significant obesity and dysbiosis in C57BL/6 mice, suggesting dietary normalization may alter microbiota composition.

Key Points

  • The high-fat diet resulted in notable increases in blood glucose and adiposity in C57BL/6 mice during the 12-week phase.
  • Body weight and adipose tissue mass rose significantly compared to controls, indicating a strong link to obesity.
  • Short-chain fatty acids were analyzed through fecal samples, showing distinct variations between diet types during the study.
  • The findings highlight potential for dietary normalization to modify dysbiosis and metabolic profiles, pointing to complex host-microbe interactions.

Cite This Study

Maria do Carmo Gouveia Pelúzio (2025) studied this question.

synapsesocial.com/papers/693624c34fa91c937236cb2ehttps://doi.org/10.3390/nu17233806
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