Serum Resolvin D1 and Maresin 1 Levels During Migraine Attacks and the Interictal Period: A Paired Analysis in Emergency Department Patients

Background/Objectives: Neurogenic inflammation plays a key role in migraine pathophysiology. This study aimed to evaluate serum Resolvin D1 (RvD1) and Maresin 1 (MaR1) levels during acute migraine attacks and in the interictal period in the same patients, using a paired design. Methods: This prospective case–control study included 55 migraine patients and 53 healthy controls. Serum samples were obtained from each patient at two time points: during an acute attack and during the subsequent interictal period. RvD1 and MaR1 concentrations were measured using ELISA. Results: Serum RvD1 and MaR1 levels were significantly lower during migraine attacks compared with both the interictal period (p = 0.006 and p = 0.001, respectively) and healthy controls (p < 0.001). Receiver operating characteristic (ROC) analyses showed moderate discriminatory ability for RvD1 (AUC 0.719) and MaR1 (AUC 0.730). Conclusions: Reduced RvD1 and MaR1 levels are associated with the acute migraine state. These findings indicate an association rather than a causal mechanism and suggest that SPM measurements may have potential as supportive adjunct biomarkers, although further validation is required.