Retrospective review shows anticoagulation does not increase postpartum hemorrhage risk in sickle cell disease pregnancies, indicating safety of prophylactic measures.
Key Points
To evaluate the risks associated with prophylactic anticoagulation during pregnancy and postpartum in patients with sickle cell disease and venous thromboembolism risk.
Single center retrospective chart review
Utilized ICD-10 codes to identify pregnancies
Collected data on VTE history, anticoagulation use, and complications
Applied generalized linear mixed model for categorical variable comparisons
Conducted univariate and multivariate analyses to calculate odds ratios
75 pregnancies were identified among 59 patients during the study period
No increase in postpartum hemorrhage or transfusion between anticoagulated and non-anticoagulated groups
Deep vein thrombosis and pulmonary embolism incidents occurred in the anticoagulated group
Statistically significant association found between postpartum hemorrhage and unplanned transfusions
Safety of prophylactic anticoagulation for pregnant patients with sickle cell disease confirmed
Cite This Study
Roberta C. G. Azbell (2025) studied this question.