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December 8, 2025BloodOpen Access

Evaluating the effect of morbid obesity on DVT in patients already on doac therapy: A retrospective analysis

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Authors

HHHashim Talib HashimFZFarigol Hakem ZadehAMAseed Mestarihi

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Overview

Retrospective analysis shows morbid obesity does not increase DVT risk in patients on DOACs, suggesting ongoing safety and efficacy.

Key Points

  • To assess outcomes of DOACs in obese patients with venous thromboembolism (VTE) and evaluate risks associated with morbid obesity.
  • Retrospective cohort study of 1,562 VTE patients on DOACs.
  • Patients were stratified by obesity status (BMI > 40).
  • Logistic regression evaluated associations with bleeding events and mortality.
  • Negative binomial regression analyzed predictors of hospital length of stay.
  • 13.0% of patients were classified as obese.
  • Obesity had no significant association with bleeding events (OR = 1.404, p = 0.2572) or mortality (OR = 0.879, p = 0.7299).
  • Obesity did not significantly affect hospital length of stay (IRR = 1.037, p = 0.6616).
  • Significant predictors of mortality included older age, male sex, and hypercoagulable state.

Cite This Study

Hashim et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d07ehttps://doi.org/10.1182/blood-2025-3122
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