Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
December 8, 2025BloodOpen Access

Sinusoidal endothelial cell-derived FGF23 modulates hematopoiesis in mice

View Full Paper
Ask AI
Bookmark
Share

Authors

SPSydney PhillipsKFKarin E. Finberg

Discussion

Loading...

Member takes

Overview

Genetic disruption of FGF23 in sinusoidal endothelial cells alters hematopoiesis and hepcidin levels in mice, suggesting a role in iron metabolism.

Key Points

  • This research aims to investigate how sinusoidal endothelial cell-derived FGF23 affects hematopoiesis and iron metabolism in mice.
  • Utilized Fgf23 conditional knockout mice and Stab2 promoter for Cre recombinase expression in SEC.
  • Conducted phlebotomy and erythropoietin injection experiments to assess FGF23 expression in bone marrow.
  • Analyzed C57BL/6 mouse models for hematological measurements and gene expression.
  • FGF23 loss in sinusoidal endothelial cells led to higher blood hemoglobin levels after phlebotomy.
  • Disrupting FGF23 in SEC resulted in reduced red cell counts in anemic models.
  • In β-thalassemia models, FGF23 disruption affected growth and iron metabolism outcomes.

Cite This Study

Phillips et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d0cdhttps://doi.org/10.1182/blood-2025-524
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Erythroid-produced intact FGF23 is a paracrine inhibitor of erythropoiesis2026 · 5 citations
  2. 2Exploring the dynamics of FGF23 in patients with Hereditary Hemochromatosis type I following iron depletive treatment: a pilot study2026
  3. 3Fgf23 expression increases atherosclerotic plaque burden in male ApoE deficient mice2024 · 1 citations
  4. 4Iron overload induced by ferric derisomaltose and ferric carboxymaltose both increase FGF-23 levels and lead to osteomalacia and bone loss in normal mice2026
  5. 5High doses of ferric derisomaltose and ferric carboxymaltose both increase FGF-23 levels and lead to osteomalacia and bone loss in healthy male mice2025