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December 8, 2025Blood

Integrating single-cell whole genome and transcriptome sequencing to track the clonal evolution of TP53-mutated myeloid neoplasms

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Authors

SSSarun SereewattanawootSCSheng F. CaiFMFrancesco Maura

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Overview

Integrating single-cell genome and transcriptome sequencing shows clonal evolution in TP53-mutated myeloid neoplasms, highlighting therapy-related implications.

Key Points

  • This research aims to understand the role of TP53 mutations in clonal evolution within myeloid neoplasms using single-cell sequencing techniques.
  • Used single-cell whole genome sequencing and transcriptome sequencing on samples from patients with TP53 mutations.
  • Identified clonal dynamics in myeloid neoplasms through analysis of copy number variations and gene expression.
  • Evaluated 28 patient samples correlated with type and presence of mutations.
  • Detected distinct modes of clonal evolution in TP53-mutated myeloid neoplasms, including patterns of clonal evolution.
  • Found that TP53 mutations precede copy number variations in disease progression.
  • Identified chr19p hypergain as a late event associated with treatment, influencing cell proliferation and resistance.

Cite This Study

Sereewattanawoot et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d147https://doi.org/10.1182/blood-2025-5014
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