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December 8, 2025Blood

The Acute Myeloid Leukemia microenvironment is defined by ineffective immune surveillance despite the presence of activated, clonally-expanded CD8 T cells with preserved effector function

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Authors

CPChad R. PottsRWRobert S. Welner

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Overview

Multi-platform analysis reveals immune surveillance issues and cytotoxic potential in leukemia-affected T cells.

Key Points

  • This research aims to understand the dynamics of CD8 T cells in acute myeloid leukemia (AML) and their immune functionalities.
  • Utilized high-dimensional proteomics and mass cytometry for profiling bone marrow samples from patients and healthy donors.
  • Performed single-cell RNA and TCR sequencing to analyze T cell populations and gene expression.
  • Employed in vivo models to interrogate CD8 T cell dynamics and responses in leukemia.
  • Identified depletion of naïve CD8 T cells and enrichment of terminal effector cells characterized by granzyme B in AML patients.
  • Found that leukemic bone marrow preserves CD8 T cells and supports their immune functions, even enhancing IFNγ production after stimulation.
  • Detected specific clonal expansions, including CMV-specific T cells, suggesting a reshaping of T cell responses in the AML microenvironment.

Cite This Study

Potts et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1dahttps://doi.org/10.1182/blood-2025-770
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