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Investigate the mechanistic role of MLLPTD in myelodysplastic syndrome and acute myeloid leukemia.

December 8, 2025BloodOpen Access

Deciphering the mechanistic role of mixed lineage leukemia partial tandem duplications (MLLPTD) in MDS and AML

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This study shows MLLPTD alters gene regulatory programs in MDS and AML, highlighting significant protein-protein interactions.

Investigate the mechanistic role of MLLPTD in myelodysplastic syndrome and acute myeloid leukemia.
Characterization of MLLPTD at transcript, protein, and genomic levels.
Quantitative mass spectrometry to assess MLL copy number and binding to chromatin.
Analysis of H3K4 trimethylation at genes bound by MLLPTD.
MLLPTD cells have lower overall MLL copy number compared to wild-type MLL cells.
Increased binding broadness to chromatin and higher H3K4 trimethylation at MLLPTD target genes.
KAT2A is identified as a preferential interactor for MLLPTD, affecting leukemogenesis in MLLPTD cells.

Dollinger et al. (2025) studied this question.

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December 8, 2025BloodOpen Access

View Full Paper

Ask AI

Bookmark

Authors

This study shows MLLPTD alters gene regulatory programs in MDS and AML, highlighting significant protein-protein interactions.

Investigate the mechanistic role of MLLPTD in myelodysplastic syndrome and acute myeloid leukemia.
Characterization of MLLPTD at transcript, protein, and genomic levels.
Quantitative mass spectrometry to assess MLL copy number and binding to chromatin.
Analysis of H3K4 trimethylation at genes bound by MLLPTD.
MLLPTD cells have lower overall MLL copy number compared to wild-type MLL cells.
Increased binding broadness to chromatin and higher H3K4 trimethylation at MLLPTD target genes.
KAT2A is identified as a preferential interactor for MLLPTD, affecting leukemogenesis in MLLPTD cells.

Dollinger et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark