What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

This research aims to compare clinical outcomes of systemic and central nervous system relapses in DLBCL patients.

December 8, 2025BloodOpen Access

Comparable PFS in isolated parenchymal cns vs systemic relapse of DLBCL: Results from a large real-world cohort

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Authors

MFMartina FilipováMasaryk University DBDavid BeladaCharles University JKJan KořenCharles University

Discussion

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Implication

Cohort analysis reveals similar progression-free survival outcomes in patients with DLBCL between CNS and systemic relapses, suggesting the need for targeted therapies.

Key Points

This research aims to compare clinical outcomes of systemic and central nervous system relapses in DLBCL patients.
Utilized a real-world cohort of 1,351 DLBCL patients who experienced their first relapse.
Patients excluded if CNS involvement was present at initial diagnosis or incomplete staging.
Compared outcomes across systemic relapse, isolated CNS relapse, and concurrent CNS/systemic relapse, focusing on progression-free survival and overall survival.
Median progression-free survival was similar for systemic and isolated CNS relapse at 8 and 7 months, respectively.
Isolated CNS relapses showed worse outcomes compared to systemic relapses based on overall survival.
Chemotherapy was administered to 1,153 patients, highlighting its significance in managing relapses.

Cite This Study

Filipová et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4c7 https://doi.org/10.1182/blood-2025-3676

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Implication

Cohort analysis reveals similar progression-free survival outcomes in patients with DLBCL between CNS and systemic relapses, suggesting the need for targeted therapies.

Comparable PFS in isolated parenchymal cns vs systemic relapse of DLBCL: Results from a large real-world cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparable PFS in isolated parenchymal cns vs systemic relapse of DLBCL: Results from a large real-world cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

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