Novel method demonstrates significant association between molecular subtypes and ctDNA dynamics in DLBCL patients, indicating improved personalized monitoring.
Key Points
To develop a novel method for molecular subtyping of diffuse large B-cell lymphoma using whole-exome sequencing data.
Analyzed WES data from 200 DLBCL patients for molecular clustering.
Applied PAM clustering and LASSO regularization to identify mutation-defined subgroups.
Used Chi-square tests to correlate molecular clusters with ctDNA dynamics.
Identified distinct molecular clusters based on mutation frequency cutoffs using WES.
Certain subtypes showed significant association with ctDNA positive or negative results.
Developed methodology demonstrates potential for improved personalized monitoring and treatment selection.