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To characterize asymptomatic monoclonal gammopathies in younger patients and assess their clinical progression.

December 8, 2025BloodOpen Access

Characteristics and clinical course of younger Patients with early lesions in a contemporary cohort of 1240 patients: Low risk features and low risk of complications

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To characterize asymptomatic monoclonal gammopathies in younger patients and assess their clinical progression.
Analyzed consecutive patients diagnosed with asymptomatic monoclonal gammopathies from 2014 to 2024
Utilized IMWG 2014 and IWWM-2/WHO criteria for classification
Examined serological markers including total serum protein and serum albumin
Among 1240 patients, 12.1% were diagnosed under age 50
Progression rates for younger patients were low, with no symptomatic events for those under 50
Cytogenetic features showed no significant differences between age groups

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Analysis reveals low progression rates of asymptomatic monoclonal gammopathies in younger patients, suggesting favorable outcomes.

Ntanasis‐Stathopoulos et al. (2025) studied this question.

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