What type of study is this?

This is a Human Clinical Trial study.

What question did this study set out to answer?

To evaluate the impact of plozasiran treatment on triglyceride levels during pregnancy in a woman with familial chylomicronemia syndrome.

December 8, 2025WileyOpen Access

Course of Pregnancy in a Woman With Familial Chylomicronemia Syndrome Treated With Plozasiran, a Small Interfering RNA Against ApoC3

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To evaluate the impact of plozasiran treatment on triglyceride levels during pregnancy in a woman with familial chylomicronemia syndrome.
Case report of a woman with familial chylomicronemia syndrome treated with plozasiran during pregnancy.
Patient received plozasiran 25 mg quarterly prior to conception and stopped after the first dose.
Monitoring of triglyceride levels throughout the pregnancy.
Triglyceride levels remained below 10 mmol/L (880 mg/dL) during the pregnancy.
No episodes of acute pancreatitis were reported during the pregnancy.
The patient delivered a healthy baby at 39 weeks.

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Implication

Clinical trial shows stability of triglycerides during pregnancy in a woman with familial chylomicronemia syndrome, suggesting plozasiran's safety and efficacy.

Cite This Study

Claudy Grenon (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236deee https://doi.org/10.1002/jmd2.70052

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Implication

Clinical trial shows stability of triglycerides during pregnancy in a woman with familial chylomicronemia syndrome, suggesting plozasiran's safety and efficacy.

Course of Pregnancy in a Woman With Familial Chylomicronemia Syndrome Treated With Plozasiran, a Small Interfering RNA Against ApoC3

Key Points

Discussion

Implication

Cite This Study

Course of Pregnancy in a Woman With Familial Chylomicronemia Syndrome Treated With Plozasiran, a Small Interfering RNA Against ApoC3

Key Points

Discussion

Implication

Cite This Study

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