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December 8, 2025Blood

Causes of death in DDX41-mutated myeloid neoplasms: A retrospective study

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Authors

DJDragan JevremovićASAntoine N. SalibaMSMithun Vinod Shah

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Overview

Retrospective study reveals infection is a key cause of death in myeloid neoplasms with DDX41 mutations, indicating the need for better prevention strategies.

Key Points

  • This research aims to identify the causes of death in patients with DDX41-mutated myeloid neoplasms.
  • Retrospective analysis of patients diagnosed with myeloid neoplasms and DDX41 mutations from 2009-2024
  • Next generation sequencing used to identify DDX41 mutations
  • Blood counts and other clinical characteristics measured at diagnosis
  • Overall survival calculated from diagnosis to death
  • 29 out of 112 patients with DDX41 mutations were deceased at analysis
  • Median overall survival of deceased patients was 29 months
  • Infections led to death in 38% of patients, while disease progression was more prevalent in AML patients

Cite This Study

Jevremović et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfc8https://doi.org/10.1182/blood-2025-7370
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decoding DDX41: Clinical impact of germline and somatic mutations in 77 high-risk myeloid neoplasm patients2025 · 1 citations
  2. 2Exploring the spectrum of non-malignant complications in germline DDX41-associated hematologic disorders2025
  3. 3Improved outcomes following allogeneic hematopoietic stem cell transplantation in patients with DDX41-mutated myeloid neoplasms: A prospective analysis of survival, GVHD, and transplant-related mortality2025
  4. 4Unsupervised clustering of DDX41 mutants informs on the somatic landscape of single germline hits2025
  5. 5Germline DDX41 mutations in myeloid neoplasms: a comprehensive review2026 · 1 citations