What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

What question did this study set out to answer?

This research aims to evaluate the characteristics and incidence of dermatologic toxicities associated with talquetamab in relapsed/refractory multiple myeloma patients.

December 8, 2025BloodOpen Access

Dermatologic toxicities associated with talquetamab in patients with Relapsed/Refractory multiple myeloma: A systematic review and meta-analysis

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Authors

ZCZaraith CoyClínica CES MCMadhu Bhargavi ChandraWellStar Health System YJYujin JeongHallym University

Discussion

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Implication

Systematic review reveals high incidence of skin toxicities in RR multiple myeloma patients treated with talquetamab, indicating need for monitoring.

Key Points

This research aims to evaluate the characteristics and incidence of dermatologic toxicities associated with talquetamab in relapsed/refractory multiple myeloma patients.
Conducted systematic review and meta-analysis
Included randomized controlled trials and observational studies
Evaluated adult patients with RR multiple myeloma receiving talquetamab
Assessed incidence of dermatological toxicity and other adverse effects
Included 8 studies with 816 patients
Overall incidence of skin toxicities was 46.9%
Efficacy demonstrated for both monotherapy and combination therapies
High occurrence of taste disorders (71.9%) and CRS (69.9%)

Cite This Study

Coy et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e0a6 https://doi.org/10.1182/blood-2025-7581

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Implication

Systematic review reveals high incidence of skin toxicities in RR multiple myeloma patients treated with talquetamab, indicating need for monitoring.

Dermatologic toxicities associated with talquetamab in patients with Relapsed/Refractory multiple myeloma: A systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Dermatologic toxicities associated with talquetamab in patients with Relapsed/Refractory multiple myeloma: A systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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