Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

DNA methylation markers assessed at birth are associated with future development of pediatric acute lymphoblastic leukemia

View Full Paper
Ask AI
Bookmark
Share

Authors

ENEric Nickels

Discussion

Loading...

Member takes

Overview

Meta analysis identifies differential methylated regions as early risk markers in pediatric acute lymphoblastic leukemia development, suggesting epigenomic influences.

Key Points

  • This research aims to identify epigenetic markers associated with the development of pediatric acute lymphoblastic leukemia (ALL) using DNA methylation data.
  • Conducted epigenome-wide association study (EWAS) on neonatal dried blood spots (DBS) from ALL cases and matched controls.
  • Analyzed DNA methylation data using Illumina EPIC and 450k platforms.
  • Applied multivariate regression controlling for factors like ALL subtype and genetic ancestry.
  • Performed meta analysis on shared probes from multiple datasets.
  • Identified a significant differentially methylated probe (cg13344587) associated with ARID5B.
  • Detected 108 differentially methylated regions (DMRs) linked to pediatric ALL.
  • Highlighted FLI1 and LAX1 as important genes with altered methylation patterns associated with ALL.

Cite This Study

Eric Nickels (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e0dbhttps://doi.org/10.1182/blood-2025-331
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DNA Methylation of Pharmacologic and Leukemia-Related Genes Predicts Clinical Outcomes in Pediatric Acute Myeloid Leukemia2026
  2. 2Prognostic relevance of epigenetic regulation of drug pharmacology and myeloid genes in pediatric AML2025
  3. 3Multiomics analysis focusing on genome‐wide DNA methylation in paediatric acute promyelocytic leukaemia2026
  4. 4The impact of periconceptional folate on the DNA methylome of acute lymphoblastic leukemia2026 · 1 citations
  5. 5A Pre-Leukemic DNA Methylation Signature in Healthy Individuals at Higher Risk for Developing Myeloid Malignancy2024 · 6 citations