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December 8, 2025BloodOpen Access

Human intestinal acute graft-versus-host disease is governed by a subset of transition-like tissue-resident memory CD8+ T cells

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Authors

XLXinyu LiuZFZhiping FanRLRen Lin

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Overview

Analysis reveals transition-like CD8+ T cells drive intestinal graft-versus-host disease severity, suggesting new targets for therapy.

Key Points

  • This research aims to investigate the role of distinct CD8+ tissue-resident memory T cell subsets in acute graft-versus-host disease in humans.
  • Examined intestinal biopsy samples from patients with and without acute graft-versus-host disease
  • Utilized single-cell RNA sequencing and multiplex immunohistochemical staining
  • Analyzed clonal expansion and differentiation trajectories of CD8+ tissue-resident memory T cells
  • Identified seven distinct CD8+ TRM cell subsets in intestinal biopsies
  • GZMK+CD8+TRMtrans subset showed higher proportions and was linked to disease severity
  • High infiltration of GZMK+CD8+TRMtrans correlated with worse survival outcomes

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1fbhttps://doi.org/10.1182/blood-2025-2453
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