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December 8, 2025Blood

Computational dissection of immune reconstitution across diverse conditioning regimens in adults with sickle cell disease undergoing allogeneic stem cell transplantation

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Authors

DGDiane M. GeorgeSPSamuel PanAAAmer Assal

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Overview

Computational analysis reveals unique immune reconstitution patterns in sickle cell disease after allogeneic stem cell transplantation, suggesting T-cell depletion strategies influence outcomes.

Key Points

  • To map lymphoid and myeloid immune recovery patterns in adults with sickle cell disease after stem cell transplantation.
  • High-dimensional flow cytometry analysis of blood samples from transplanted sickle cell disease adults and healthy controls.
  • Utilized 43-marker panel to compare immune recovery across different conditioning regimens.
  • Engraftment kinetics and lineage chimerism analyzed from a larger patient cohort alongside detailed immunophenotypic assessments.
  • Sickle cell disease patients showed distinct immune reconstitution with a B-cell skew at baseline.
  • CD34-selected grafts provided faster recovery of neutrophils and a myeloid-dominant landscape compared to TBI and PTCy.
  • Different regimens influenced specific immune cell recoveries, with CD34 selection enhancing early B-cell reconstitution while PTCy favored NK and plasma cells.

Cite This Study

George et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e239https://doi.org/10.1182/blood-2025-4255
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