Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Comparison of 80 mg/kg vs. 100 mg/kg post-transplant cyclophosphamide dose with flu/mel and allogeneic transplant: Less is not more

View Full Paper
Ask AI
Bookmark
Share

Authors

RMRichard T. MaziarzJSJennifer N. Saultz

Discussion

Loading...

Member takes

Overview

Retrospective review finds similar overall survival comparing 80 mg/kg vs. 100 mg/kg cyclophosphamide, suggesting effective GVHD prevention with reduced toxicity.

Key Points

  • To compare outcomes of 80 mg/kg and 100 mg/kg post-transplant cyclophosphamide in patients receiving FluMel100 conditioning for GVHD prevention.
  • Single-center retrospective chart review
  • Examined disease response, toxicity, and GVHD outcomes in patients receiving either PTCy 100 mg/kg or 80 mg/kg
  • Evaluated 1-year overall survival, relapse-free survival, acute GVHD incidence, and other transplant-related outcomes
  • Similar 1-year overall survival rates: 92.6% (PTCy80) vs. 85.2% (PTCy100)
  • No significant differences in overall survival, relapse rates, and 100-day survival
  • Higher incidence of acute GVHD in PTCy80 group (63.0% vs. 33.3% for PTCy100)
  • Earlier onset of aGVHD in PTCy80 group (39 vs. 44 days)

Cite This Study

Maziarz et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e23bhttps://doi.org/10.1182/blood-2025-4252
View Full Paper
Ask AI
Bookmark
Share