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December 8, 2025Blood

Effectiveness and safety profile of pola-based regimen in DLBCL Patients with high-risk factors in real world: A retrospective study in China

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Authors

MLMiaomiao Liu

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Overview

Retrospective study shows efficacy of pola-based regimens in high-risk DLBCL patients, indicating manageable toxicity profiles.

Key Points

  • Evaluate the effectiveness and safety of pola-based regimens in DLBCL patients with high-risk factors.
  • Retrospective analysis of 30 DLBCL patients treated with pola-based regimens
  • Efficacy evaluated via PET/CT or contrast-enhanced CT scans
  • Treatment responses assessed using the 2014 Lugano criteria
  • Adverse events graded by NCI-CTCAE v5.0
  • Half of the evaluable patients achieved complete response (CR)
  • Manageable toxicity with 37.5% experiencing grade 3-4 adverse events
  • Anemia was the most common adverse event, affecting 100% of patients
  • Median follow-up was 3.8 months, with only 2 patients progressing

Cite This Study

Miaomiao Liu (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2aehttps://doi.org/10.1182/blood-2025-7222
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