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December 8, 2025Blood

Direct oral anticoagulation management to address primary and secondary adherence in atrial fibrillation

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Authors

JAJan AndersonEBEllie Balken

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Overview

Quality improvement initiative demonstrated improved patient outcomes in adherence to direct oral anticoagulants for atrial fibrillation, addressing barriers like cost and adverse effects.

Key Points

  • Evaluate interventions to enhance adherence to direct oral anticoagulants in atrial fibrillation patients.
  • Conducted a quality improvement initiative targeting patients with atrial fibrillation receiving DOACs.
  • Utilized Surescripts data to assess primary and secondary adherence levels before and after intervention.
  • Implemented a pharmacy-led DOAC management unit to assist with adherence challenges.
  • Primary adherence improved from 84% to 91% following interventions.
  • Secondary adherence increased from 86% to 96% during the initiative.
  • Cost, adverse effects, and perceived benefits were key barriers to adherence.

Cite This Study

Anderson et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e43chttps://doi.org/10.1182/blood-2025-6168
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