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December 8, 2025Blood

Treatment responses and survival of newly diagnosed older or unfit patients (pts) with IDH1/2-mutated Acute Myeloid Leukemia (AML): An analysis of the MARROW consortium

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Authors

OCOnyee ChanMWMichael J. WalkerDNDeedra Nicolet

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Overview

Retrospective analysis of therapies shows improved survival with venetoclax in older AML patients with IDH mutations.

Key Points

  • To assess treatment responses and survival outcomes for older or unfit patients with IDH1/2-mutated Acute Myeloid Leukemia.
  • Retrospective analysis of 939 patients with IDH1/2 mutations
  • Comparison of frontline and second-line treatment regimens
  • Evaluation of treatment responses and survival rates
  • 60% of patients received venetoclax as initial therapy
  • IDH1-mutated patients had higher overall survival with venetoclax vs HMA
  • JAK2 mutations were linked to inferior survival outcomes

Cite This Study

Chan et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e452https://doi.org/10.1182/blood-2025-1626
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IDH1 mutation predicts response and survival in treatment-naïve Acute Myeloid Leukemia patients receiving with venetoclax with a hypomethylating agent2025
  2. 2Outcomes and characteristics of patients treated with frontline intensive chemotherapy versus hypomethylating agent/venetoclax-based therapy in DDX41-mutated Acute Myeloid Leukemia (AML)2025
  3. 3IDH mutant MDS: Proposal for disease subset recognition based on molecular and clinical features, and the availability of targeted therapies2025
  4. 4A multicenter real-world study on response and survival in older patients with acute myeloid leukemia treated with intensive chemotherapy versus VEN/HMA by 2022 and 2024 ELN risk stratifications: An analysis from the MARROW consortium2025
  5. 5Determinants of survival in 356 patients failing frontline HMA-Ven for newly-diagnosed AML.2026