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December 8, 2025BloodOpen Access

Sex-based disparities in MPN treatment patterns: A study of 1167 patients from the Quebec MPN registry

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Authors

LBLambert Busque

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Overview

Analysis identifies sex-driven disparities in therapeutic strategies for myeloproliferative neoplasms, suggesting tailored approaches are necessary.

Key Points

  • The study aims to assess sex-specific treatment patterns in patients with myeloproliferative neoplasms.
  • Analyzed clinical data from 1167 patients with WHO-defined MPN from the Quebec MPN registry.
  • Examined disease-specific risk stratification models and treatment protocols.
  • Utilized standard statistical methods to compare treatment approaches and outcomes based on sex.
  • Women made up 55% of the patient group with comparable age at diagnosis between sexes.
  • Significantly more women had less need for phlebotomy compared to men (p=0.0017).
  • Treatment discontinuation reasons varied by sex; intolerance was more common in women, while resistance and death were more frequent in men.

Cite This Study

Lambert Busque (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e477https://doi.org/10.1182/blood-2025-723
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