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The study aims to assess the impact of guideline-based management in sickle cell nephropathy with a focus on UACr levels.

December 8, 2025BloodOpen Access

Keeping it renal: Results of applying guideline-based management in sickle cell nephropathy

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Retrospective study shows ACEi/ARB improves UACr in sickle cell anemia, suggesting need for better adherence.

The study aims to assess the impact of guideline-based management in sickle cell nephropathy with a focus on UACr levels.
Retrospective study of 255 sickle cell anemia patients aged 19-60
Collected UACr, creatinine, eGFR, and ACEi/ARB prescription data
Used two-sample t-tests for statistical analysis
56.1% of patients had microalbuminuria
ACEi/ARB prescribed to 85% of patients with microalbuminuria
Initiation of ACEi/ARB significantly decreased UACr from 324.34 to 242.83 mg/g

Wernecke et al. (2025) studied this question.

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