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December 8, 2025Blood

Targeted salvage therapy improves survival in B-ALL relapsing after CD19 CAR-T: A multi-institutional study

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Authors

QTQianshan Tao

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Overview

Retrospective analysis reveals targeted salvage therapies improve survival in relapsed B-ALL, emphasizing CNS involvement.

Key Points

  • To define optimal treatment strategies for patients with relapse after CD19 CAR-T therapy in B-ALL.
  • Conducted a retrospective multi-institutional study involving 74 relapsed B-ALL patients.
  • Analyzed clinical characteristics, salvage regimens, and survival outcomes.
  • Utilized IBM SPSS and R software for survival analysis.
  • 32 patients (47.8%) achieved complete remission post-salvage therapy.
  • Targeted salvage therapy resulted in a median overall survival of 8.6 months.
  • CNS relapse showed significantly higher complete remission rates compared to non-CNS involvement.

Cite This Study

Qianshan Tao (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4dahttps://doi.org/10.1182/blood-2025-6854
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