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December 8, 2025BloodOpen Access

Impact of blood transfusion on clinical outcomes in patients hospitalized with acute promyelocytic leukemia: A nationwide analysis

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Authors

AGAdamsegd Isac GebremedhenBTBishal Tiwari

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Overview

Nationwide analysis reveals blood transfusion does not increase mortality but raises sepsis and organ failure rates in hospitalized APL patients.

Key Points

  • Evaluate the effect of blood transfusions on in-hospital outcomes in patients with acute promyelocytic leukemia.
  • Identified patients aged ≥18 with APL using ICD-10-CM codes from the National Inpatient Sample database
  • Compared demographic and clinical characteristics between transfused and non-transfused groups
  • Utilized multivariable logistic and Poisson regression models to assess associations
  • No significant difference in all-cause in-hospital mortality between transfused and non-transfused groups
  • Transfused patients had higher odds of developing sepsis (aOR 1.70) and organ failure
  • Transfused patients had longer hospital stays (mean LOS 27.36 days vs. 22.01 days)
  • Total hospitalization costs were significantly higher in transfused patients ($430,436 vs. $336,041)

Cite This Study

Gebremedhen et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5bfhttps://doi.org/10.1182/blood-2025-6909
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