What question did this study set out to answer?

To explore the predictive capability of hub genes within a pan-cancer co-expression network for drug responses.

February 21, 20500 citationsOpen Access

Hub genes in a pan-cancer co-expression network show potential for predicting drug responses

FAFrancisco AzuajeUniversity College Dublin TKTony KaomaUniversity of Luxembourg CJCéline JeantyCentre de Recherche en Mathématiques de la Décision

Key Points

To explore the predictive capability of hub genes within a pan-cancer co-expression network for drug responses.
Utilized dataset of gene co-expression network data to identify hub genes.
Performed qPCR for independent validation of findings.
Compiled supplementary figures to support the research.
Identified key hub genes in the pan-cancer co-expression network.
Demonstrated strong potential for predicting drug responses across different cancer types.

Abstract

Dataset 1. Gene co-expression network data. It contains network nodes, weighted network and list of hubs. Dataset 2. qPCR data from independent validation, including MIQE and additional information. Dataset 3. Supplementary Figures. Legends are included under each figure. Dataset 4. Full qPCR data (including raw Cq values).

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