Using routine blood tests to predict severe immune-related adverse events during immune checkpoint inhibitor treatment

Q: What type of study is this?

This is a Validation Study study.

Caner Acar; Fatma Pınar Açar; Gökhan Şahin; Haydar Çağatay Yüksel; Burçak Karaca; Erdem Göker

doi:10.1186/s12885-025-15460-7

December 13, 2025BMC CancerOpen Access

Using routine blood tests to predict severe immune-related adverse events during immune checkpoint inhibitor treatment

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Key Points

The study aims to identify predictors of severe immune-related adverse events (irAEs) in patients undergoing immune checkpoint inhibitor treatment.
Analysis of baseline blood tests including eosinophil count and RDW.
Assessment of the relationship between these tests and severe irAEs during therapy.
Consideration of personalized monitoring for patient selection.
High baseline eosinophil count is linked to increased risk of severe irAEs.
Lower RDW early in treatment is associated with higher risk of severe adverse effects.
The findings suggest potential for using these tests in clinical practice prior to external validation.

Implication

Findings report high baseline eosinophil count and low RDW increase risk of severe immune-related adverse events during therapy, suggesting new monitoring strategies.

Abstract

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Cite This Study

Acar et al. (2025) studied this question.

synapsesocial.com/papers/694018f82d562116f28f5d67 https://doi.org/10.1186/s12885-025-15460-7

View Full Paper

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Using routine blood tests to predict severe immune-related adverse events during immune checkpoint inhibitor treatment

Key Points

Implication

Abstract

Discussion

Cite This Study

Using routine blood tests to predict severe immune-related adverse events during immune checkpoint inhibitor treatment

Key Points

Implication

Abstract

Discussion

Cite This Study

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