Graveoumarins A–C: chiral resolution, absolute configuration, and anticoagulant/anti-inflammatory activities of 3′-methyl-3′-butenyl coumarins from ruta graveolens L

This study successfully characterized the chirality and determined the absolute configurations of specific 3'-methyl-3'-butenylcoumarins from R. graveolens, including the discovery of three new compounds. While most isolated compounds lacked significant anticoagulant or anti-inflammatory activity in the tested models, racemic (±)-3 showed moderate anti-inflammatory potential by inhibiting NO production. These findings provide new insights for the future development and utilization of coumarins from R. graveolens.