High-Throughput Mechanical Characterization of Giant Unilamellar Vesicles by Real-Time Deformability Cytometry

Maximilian Kloppe; Stefan J. Maurer; Tobias Abele; Kerstin Göpfrich; Sebastian Aland

doi:10.1039/d5sm01140j

December 12, 2025Soft MatterOpen Access

High-Throughput Mechanical Characterization of Giant Unilamellar Vesicles by Real-Time Deformability Cytometry

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Key Points

To evaluate the mechanical properties of giant unilamellar vesicles (GUVs) using real-time deformability cytometry.
Applied real-time deformability cytometry (RT-DC) for high-throughput analysis.
Characterized soft microscopic objects without contact.
Analyzed deformation patterns of giant unilamellar vesicles.
Demonstrated high-throughput capabilities for characterizing vesicles.
Provided insights into vesicle deformation mechanics.

Implication

Mechanical characterization improves understanding of vesicle properties through high-throughput analysis.

Abstract

Real-time deformability cytometry (RT-DC) enables high-throughput, contact-free mechanical characterization of soft microscopic objects. Here we apply this technique to giant unilamellar vesicles (GUVs). To interpret vesicle deformation in RT-DC, we...

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Cite This Study

Kloppe et al. (2025) studied this question.

synapsesocial.com/papers/694019032d562116f28f60d9 https://doi.org/10.1039/d5sm01140j

View Full Paper

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High-Throughput Mechanical Characterization of Giant Unilamellar Vesicles by Real-Time Deformability Cytometry

Key Points

Implication

Abstract

Discussion

Cite This Study

High-Throughput Mechanical Characterization of Giant Unilamellar Vesicles by Real-Time Deformability Cytometry

Key Points

Implication

Abstract

Discussion

Cite This Study

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