Purification reveals a trinorditerpene with significant cytotoxicity in MCF-7 and antioxidant activity, suggesting potential therapeutic applications.
Natural products derived from plants have been extensively developed as alternative medicines due to their relatively minimal side effects. Here we present the purification and characteristics of parasitic acid, a novel trinorditerpene from Dysoxylum parasiticum leaf extract, and investigate various bioactivities. The structure of this compound was elucidated using extensive spectroscopic techniques, including 1D and 2D NMR, and high-resolution mass spectrometry, which revealed a unique trinorditerpene skeleton featuring a 3-carboxyfuran moiety. The purified trinorditerpene exhibited cytotoxicity against MCF-7 (IC50 29.0 ± 0.8 μg/mL), antioxidant effects in the DPPH radical scavenging assay (IC50 10.91 ± 0.04 μg/mL), and inhibition of α-glucosidase enzyme (IC50 36 ± 1 μg/mL). Docking studies were also undertaken to explore the binding activities. This is the first report of a trinorditerpene-type diterpene from D. parasiticum with this unique combination of biological activities.
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Mahon et al. (2025) studied this question.
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