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This research aims to improve the retention of polar compounds in reversed-phase liquid chromatography using surfactants.

December 12, 2025SeparationsOpen Access

Analysis of Highly Polar Compounds by Ion-Pair Liquid Chromatography

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This research aims to improve the retention of polar compounds in reversed-phase liquid chromatography using surfactants.
Used RPLC with C18 columns and low acetonitrile percentages (10-20%)
Examined retention using sodium dodecyl sulfate (SDS) concentrations from 0 to 0.3 mM
Investigated the impact of temperature (25-55 °C) and equilibration time on retention
Enhanced retention of polar compounds like sulfonamides when using SDS
Retention behavior followed a linear pattern below critical micellar concentration
Emphasized the importance of partial equilibration for consistent results

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Analysis demonstrates improved retention of polar compounds with surfactant SDS in RPLC, suggesting new methods for separation.

Tereba-Mamani et al. (2025) studied this question.

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