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December 12, 2025Behavioral Sciences2 citationsOpen Access

Prevention of Postpartum Depression via a Digital ACT-Based Intervention: Evaluation of a Prototype Using Multiple Case Studies

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ANAnna NicolettiSRSilvia RizziSFStefano Fait

Key Points

  • Evaluate the effectiveness of a digital chatbot intervention based on Acceptance and Commitment Therapy for preventing postpartum depression.
  • Developed a low-fidelity chatbot prototype (REA) for supporting women during late pregnancy and early postpartum.
  • Nineteen participants interacted with the chatbot, completed questionnaires, and engaged in semi-structured interviews.
  • Quantitative data analyzed using Wilcoxon signed-rank test; qualitative data analyzed through thematic analysis.
  • Quantitative analysis indicated significant improvements in scores related to empathy, clarity, engagement, and usability.
  • Qualitative feedback showed high levels of appreciation for the chatbot's supportive features.
  • Participants highlighted the chatbot’s engaging nature, appropriate language, and smooth interaction flow.

Abstract

Postpartum depression (PPD) affects up to 15% of mothers, yet access to preventive psychological interventions during pregnancy remains limited. Acceptance and Commitment Therapy (ACT) has demonstrated efficacy in promoting psychological flexibility and preventing mental distress. Nevertheless, no studies have yet evaluated its use for the prevention of PPD through a chatbot-based digital intervention. The present study describes the development and preliminary evaluation of an ACT-based chatbot intervention (REA) to support women during late pregnancy and the early postpartum period. Nineteen participants interacted with the low-fidelity REA prototype, explored its features, completed two questionnaires, and then participated in semi-structured interviews. Quantitative data were analysed using the Wilcoxon signed-rank test; qualitative data were analysed using thematic analysis. Quantitative analysis revealed significantly elevated scores for the majority of variables, including empathy and listening, fluency, lexicon, clarity, engagement, functionality, aesthetics, information, and perceived impact. The interview findings demonstrated a notable level of appreciation for the intervention. The participants described the chatbot as engaging and supportive, highlighting a smooth interaction flow, content-appropriate language, and messages of suitable length. The REA prototype demonstrated high acceptability, usability, and perceived usefulness among a diverse range of stakeholders, thus supporting its potential as a scalable, stigma-reducing tool for the prevention of PPD. Subsequent research endeavours will focus on refining the chatbot’s personalisation features and conducting comprehensive clinical trials to evaluate its efficacy.

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Cite This Study

Nicoletti et al. (2025) studied this question.

synapsesocial.com/papers/6940190c2d562116f28f64d2https://doi.org/10.3390/bs15121723
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