Catalytic method generates aromatic trifluoropropynyl derivatives in high yield, implying broad application in synthesis.
The synthesis of aromatic trifluoromethylated scaffolds is of considerable importance in organic chemistry and pharmaceutical research. Herein, a catalytic method with broad functional group tolerance for the construction of aromatic and heteroaromatic trifluoropropynyl derivatives is reported. This methodology is based on a tandem Sonogashira cross‐coupling reaction between an hydrofluoroolefins‐based carbinol and (hetero)aryl iodides. The developed protocol employs inexpensive and commercially available HFO‐1234yf gas to generate a bench‐stable trifluoropropynyl carbinol reagent.
No takes yet. Share an insight, caveat, or question.
Bodnár et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: