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December 12, 2025Asian Journal of Organic Chemistry2 citations

Muconic Acid: An Underexplored Building Block for Fine Organic Synthesis

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APAndrey I. PuzanovDZDmitriy N. ZakusiloEIE. V. Ipatova

Key Points

  • To explore the potential of muconic acid as a valuable precursor in organic synthesis.
  • Reviewed recent achievements in muconic acid production and transformations
  • Discussed chemical reactions including Diels‐Alder reactions and polymerization
  • Examined applications in fine organic synthesis
  • Muconic acid can be produced from renewable lignocellulosic materials
  • It can be hydrogenated into adipic acid for nylon production
  • Muconic acid's derivatives are useful in multiple synthetic transformations

Abstract

ABSTRACT This mini review describes recent achievements in the production and chemical transformations of muconic acid (hexa‐2,4‐dienedioic acid, HO 2 CCH═CHCH═CHCO 2 H). Muconic acid may be obtained from renewable lignocellulosic materials, and it is considered as a bio‐based platform molecule. This acid has a great practical value due to its hydrogenation into adipic acid, which is used for nylon production. Muconic acid and its derivatives take part in many important and useful synthetic transformations such as Diels‐Alder reactions, isomerization, lactonization, polymerization, polycondensation, and others. However, up to the moment, muconic acid is not yet widely used in the fine organic synthesis. This review is focused on preparation, reactions, and on some novel applications of muconic acid and its derivatives in organic synthesis. The aim of this review is to attract attention to muconic acid, which has a high potential to be a valuable precursor for preparation of novel compounds and materials.

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Cite This Study

Puzanov et al. (2025) studied this question.

synapsesocial.com/papers/694019192d562116f28f6779https://doi.org/10.1002/ajoc.70286
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