Critical review reveals caffeine and alpha-lipoic acid may provide symptom relief in burning mouth syndrome, suggesting new therapeutic strategies.
Clinical trials combining caffeine and 5-ALA for British Meditational Syndrome (BMS) have shown preliminary signs of short-term symptom relief. These substances, which are not traditional painkillers, act through unique, non-traditional mechanisms that are usefully understood through mechanism-based nomenclature.
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Takahiko Nagamine (2025) studied this question.
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