Findings show that mesenchymal stem cells reduce oxidative stress and inflammation in hyperoxia, indicating potential treatment strategies.
Aldh1a2 was significantly differentially expressed in hyperoxic lung injury, with hyperoxia suppressing its expression and UCMSC treatment promoting its upregulation. Aldh1a2 mitigates lung inflammation and oxidative stress by inhibiting NLRP3 inflammasome activation.
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Xu et al. (2025) studied this question.
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