This research shows enhanced efficiency in gene drives using multiplexing strategies, suggesting increased tolerance to resistance.
Future drive designs requiring a larger number of gRNAs could potentially be improved. The design relying on extended homology arms may not represent an optimal strategy. However, population-level multiplexing gRNAs could serve as a promising alternative, enhancing efficiency while maintaining tolerance to functional resistance.
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Chen et al. (2025) studied this question.
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