This protocol enables glycosylation and tuning reactivity in oligosaccharide assembly, suggesting efficient strategies using thiophene donors.
A thiophene-scaffolded alkyne-activating glycosyl donor has been developed, enabling fine reactivity control through ring-size modulation. The expanded spatial arrangement between the carbonyl and alkyne units confers distinct reactivity compared to the classical Yu's donor, facilitating efficient one-pot oligosaccharide assembly under single activation conditions. This reactivity differentiation also supports orthogonal, reactivity-based glycosylation strategies. The thiophene-based ATC donor is readily prepared, bench-stable, and broadly applicable, providing a practical and tunable platform for programmable glycosylation.
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Tian et al. (2025) studied this question.
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