This research shows antifungal susceptibility and genetic relatedness of aspergillus species in chronic pulmonary aspergillosis patients, suggesting environmental sources impact disease acquisition.
Chronic pulmonary aspergillosis (CPA) comprises a spectrum of lung disorders caused by ubiquitous fungi of the genus Aspergillus, with A. fumigatus being the most frequently identified pathogen. The disease is globally prevalent and associated with significant morbidity and mortality. Here, we investigated the species distribution, antifungal susceptibility and genetic relatedness of Aspergillus isolates from CPA patients and environmental sources in South India. All tested isolates were susceptible to common antifungals and A. fumigatus was overall the most common species. Isolates from patients and the environment occasionally displayed identical genotypes, suggesting CPA patients acquire the disease from the environment.
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Spruijtenburg et al. (2025) studied this question.
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